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Diamine oxidase (DAO)

206 zł
Readiness of result: from 14 day
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Why this test?

Diagnostics and differential diagnosis of lack of tolerance to histamine from IgE-induced allergy and other histamine-associated disorders (chronic inflammation of the intestinal mucosa in Crohn's disease, ulcerative colitis, etc.). 

Appoint and monitor therapy and a histamine-free diet in a timely manner.

In what cases is it prescribed? 

For the diagnosis of histamine intolerance. 

Differential diagnosis of histamine intolerance from IgE-induced allergy, chronic inflammation of the intestinal mucosa (with Crohn's disease, ulcerative colitis, etc.). 

Monitoring of the course, control of histamine-free diet therapy.

Test information 

Diamine oxidase (DAO, DAO) is an enzyme that plays a key role in the breakdown of histamine that comes with food. Histamine is a biogenic amine, synthesized from the amino acid histidine in mast cells, basophils, platelets, and some neurons, where it is located intracellularly in vesicles, is released upon stimulation, and is a mediator of allergic and pseudoallergic reactions. 

Histamine intolerance (HTG) is a state of intolerance to histamine that comes with food, the cause of which is a deficiency/insufficient activity of the enzyme diamine oxidase or a change in the ratio of the intake of histamine and the enzyme, which is manifested by clinical symptoms similar to those of allergic diseases. VTG is observed in 1% of the population of various countries of the world, up to 80% are middle-aged women. 

Nonallergic factors that release histamine/block DAO and lead to VTG include histamine-rich foods, drugs, chemical and physical agents, alcohol, hypoxia, neuropeptides, enzymes, and enterocyte damage in gastrointestinal disease , lack of vitamin B6. Histamine in VTH accumulates in the body and causes general allergic symptoms (Non-IgE-mediated allergy), which are often interpreted as symptoms of food allergy. DAO-associated genetic predisposition to delayed destruction of histamine is poorly studied.

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How to prepare for testing?
Do not eat 12 hours before the study
Do not eat 12 hours before the study
You can drink clean still water
You can drink clean still water
Eliminate physical and emotional stress for 30 minutes before the study
Eliminate physical and emotional stress for 30 minutes before the study
Do not smoke for 30 minutes before the study
Do not smoke for 30 minutes before the study
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