Diphtheria Toxoid, IgG antibodies
Why this test?
- To diagnose diphtheria.
- To assess the intensity of anti-diphtheria immunity when determining the expediency of revaccination and monitoring its effectiveness.
- For differential diagnosis (along with other studies) in diseases with similar symptoms, such as tonsillitis of various etiologies, paratonsillar abscess, infectious mononucleosis, acute laryngotracheitis, epiglottitis, bronchial asthma.
In what cases is it prescribed?
- With symptoms of diphtheria infection - twice (on the 1st-3rd and 7-10th day of the disease).
- When determining indications for vaccination or revaccination.
- If it is necessary to evaluate the effectiveness of vaccination against diphtheria - before and after the administration of the vaccine with an assessment of the titer of antibodies in dynamics.
Diphtheria is an acute infectious disease transmitted by airborne droplets, the causative agent of which is Corynebacterium diphtheriae (BL, Leffler's bacilli), which produce diphtheria toxin. The source of infection is a sick person or a bacterial carrier.
The incubation period is on average 2-5 days. The clinical picture of the disease is characterized by fibrinous inflammation of the mucous membranes of the oropharynx and respiratory tract and phenomena of general intoxication. With a toxic form of diphtheria, the heart and nervous system can also be affected.
In response to infection with the causative agent of diphtheria or to vaccination with diphtheria toxoid, the immune system produces antitoxic antibodies in the blood on the 1st-3rd day of the disease, the high titer of which persists for several weeks.