CA-125 (Ovarian Cancer Test)

About the Test

CA 125 is a protein often found on the surface of ovarian cancer cells and in some normal tissues. It is used as a marker for ovarian cancer. However, CA 125 levels may also be high in other types of non-cancerous conditions, including menstruation, pregnancy, and pelvic inflammatory disease.

Purpose of the test

Before a patient starts treatment for ovarian cancer, the doctor will measure CA 125 to be able to compare it with future measurements. During therapy, doctors use CA 125 testing, at intervals, to follow the response to therapy. CA 125 may also be measured several times after therapy is completed to catch any early signs of cancer’s return. 

CA 125 may also be requested by your doctor if you have persistent or frequent symptoms (e.g. unexplained tummy pain, bloating, feeling full, and/or loss of appetite or problems with urination) to determine if you require an ultrasound scan of the abdomen and pelvis.